食品伙伴网讯  据欧盟食品安全局（EFSA）消息，欧盟食品安全局食品添加剂和营养源专家组（ANS）重新评估了脂肪酸丙二醇酯（propane‐1,2‐diol esters of fatty acids，E477）作为食品添加剂的安全性。

 

　　通过评估，欧盟专家小组得出结论认为，脂肪酸丙二醇酯在目前的授权使用水平中不存在安全问题，建议作为食品添加剂每日最大摄入量（ADI）为80 mg/kg bw。

 

　　部分原文报道如下：

 

　　The EFSA Panel on Food Additives and Flavourings （FAF） provides a scientific opinion re‐evaluating the safety of propane‐1,2‐diol esters of fatty acids （E 477） when used as a food additive. The Scientific Committee on Food （SCF） in 1978 endorsed the acceptable daily intake （ADI） of 25 mg/kg body weight （bw） per day, expressed as propane‐1,2‐diol, established by the Joint FAO/WHO Expert Committee on Food Additives （JECFA） in 1974. No adverse effects were observed in short‐term studies in rats and dogs at the highest doses tested. The Panel considered that E 477 did not raise a concern for genotoxicity. No chronic toxicity, carcinogenicity, reproductive and developmental toxicity studies with propane‐1,2‐diol esters of fatty acids were available to the Panel. The Panel considered that any potential adverse effect of propane‐1,2‐diol ester of fatty acids would be due to propane‐1,2‐diol, previously re‐evaluated as a food additive and for which an ADI of 25 mg/kg bw per day was established. Considering the overall metabolic and toxicity database, the Panel confirmed the previously established ADI for propane‐1,2‐diol esters of fatty acids （E 477） of 25 mg/kg bw per day expressed as propane 1,2 diol. This corresponds to an ADI for E 477 of 80 mg/kg bw per day, based on the concentration of free and bound propane‐1,2‐diol amounting to a maximum of 31% as laid down in the EU specification. The Panel concluded that there would not be a safety concern at the reported use levels for E 477 because exposure estimates from the refined non‐brand loyal scenario did not exceed the ADI for E 477 in any of the population groups. However, the Panel aims to explore the feasibility of establishing a group ADI for those food additives that result in an exposure to propane‐1,2‐diol, such as E 477, E 1520 and E 405. Additionally, the Panel will also consider performing a combined exposure assessment to propane‐1,2‐diol resulting from the use of these food additives. The Panel also recommended some modifications of the EU specifications for E 477.

 

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