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欧盟评估一种β-环糊精葡萄糖基转移酶的安全性

放大字体  缩小字体 时间:2020-10-12 10:48 来源:食品伙伴网 作者: 泽夕   
核心提示:2020年10月1日,欧盟食品安全局就一种β-环糊精葡萄糖基转移酶(β‐cyclodextrin glucanotransferase)的安全性评价发布意见。
   食品伙伴网讯  2020年10月1日,欧盟食品安全局就一种β-环糊精葡萄糖基转移酶(β‐cyclodextrin glucanotransferase)的安全性评价发布意见。
 
  据了解,这种食品酶是由Wacker Chemie GmbH公司用转基因大肠肝菌(Escherichia coli )菌株WCM105xpCM6420生产的。由于缺乏关于这种β-环糊精葡萄糖基转移酶与已知过敏原的序列同源性的信息,专家小组无法完成对这种食物酶过敏原性的评估。因此该食品酶不能被认为是安全的。部分原文报道如下:
 
  The food enzyme β‐cyclodextrin glucanotransferase ((1→4)‐α‐d‐glucan 4‐α‐d‐[(1→4)‐α‐d‐glucano]‐transferase; EC 2.4.1.19) is produced with a genetically modified Escherichia coli strain WCM105xpCM6420 by Wacker Chemie GmbH. The production strain harbours a self‐replicating multicopy plasmid which contains genes conferring resistance to two highly important antimicrobials for human and veterinary medicine. The food enzyme is free from viable cells of the production organism, but not of its recombinant DNA. Therefore, the food enzyme poses a risk of promoting the spread of antimicrobial resistance genes. It is intended to be used in starch processing for the production of γ‐cyclodextrin. Residual amounts of total organic solids are removed by the purification steps applied during the production of γ‐cyclodextrin; consequently, dietary exposure was not calculated. A bacterial reverse mutation test was not considered, because the representativeness of the test material could not be established. No other toxicological tests were provided. In the absence of information about the sequence homology of this β‐cyclodextrin glucanotransferase with known allergens, the Panel could not complete the assessment on the allergenicity of the food enzyme. The Panel concludes that the food enzyme β‐cyclodextrin glucanotransferase produced with the genetically modified E. coli strain WCM105xpCM6420 cannot be considered safe.
 
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日期:2020-10-12
 
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