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欧盟评估一种磷脂酶C的安全性

放大字体  缩小字体 时间:2020-07-16 10:29 来源:食品伙伴网 作者: 泽夕   
核心提示:2020年7月15日,欧盟食品安全局(EFSA)发布一种食品酶磷脂酶C(enzyme phospholipase C)安全性的评估结果。
   食品伙伴网讯  2020年7月15日,欧盟食品安全局EFSA)发布一种食品酶磷脂酶C(enzyme phospholipase C)安全性的评估结果。
 
  据了解,这种食品酶是由Novozymes A/S公司用转基因地衣芽孢杆菌( Bacillus licheniformis)菌株NZYM-VR生产的,旨在用于油脂的脱胶中。经过评估,专家小组得出结论,这种食品酶在预期使用条件下不会引起安全问题。部分原文报道如下:
 
  The food enzyme phospholipase C (phosphatidylcholine cholinephosphohydrolase EC 3.1.4.3) is produced with the genetically modified Bacillus licheniformis strain NZYM ‐VR by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA . This phospholipase C is intended for use in degumming of fats and oils. The residual amounts of Total Organic Solids (TOS ) are removed during washing and purification steps applied during degumming. Consequently, no dietary exposure was calculated. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a No Observed Adverse Effect Level (NOAEL ) at the highest dose tested of 714 mg TOS /kg body weight (bw) per day. Similarity of the amino acid sequence to those of known allergens was searched for and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood is considered to be low. based on the data provided and the removal of TOS during the degumming of fats and oils, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
 
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日期:2020-07-16
 
 
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