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欧盟评估添加剂Nilablend™ 200G对育肥鸡的安全性和有效性

放大字体  缩小字体 时间:2021-03-23 14:33 来源:食品伙伴网 作者: 泽夕   
核心提示:2021年3月22日,据欧盟食品安全局(EFSA)消息,应欧盟委员会要求,欧盟动物饲料添加剂和产品(FEEDAP)研究小组就饲料添加剂Nilablend™ 200G对育肥鸡的安全性和有效性发表科学意见。
   食品伙伴网讯  2021年3月22日,据欧盟食品安全局EFSA)消息,应欧盟委员会要求,欧盟动物饲料添加剂和产品(FEEDAP)研究小组就饲料添加剂Nilablend 200G对育肥鸡的安全性和有效性发表科学意见。

  据了解,Nilablend 200G的活性物质为拉沙洛西钠(lasalocid A sodium)和尼卡巴嗪(nicarbazin),作为育肥鸡饲料的抗球虫剂。部分原文报道如下:
 
  Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the coccidiostat Nilablend 200G containing lasalocid A sodium and nicarbazin. Nilablend 200G is not safe for chickens for fattening at the proposed maximum use level of 50 mg lasalocid A sodium + 50 mg nicarbazin/kg complete feed. Concurrent administration of Nilablend 200G (containing lasalocid A sodium) with tiamulin and certain other medicinal substances should be avoided. Lasalocid A sodium has antimicrobial activity against Gram‐positive bacterial species while many Enterobacteriaceae are naturally resistant. Induction of resistance and/or cross‐resistance was not observed in experimental conditions. No information on the interactions of nicarbazin with feed materials, other approved additives or medicinal products have been provided. No data were submitted on the microbiological safety of nicarbazin. The toxicological package for lasalocid A sodium and nicarbazin identified no observed adverse effect levels (NOAELs) that could be the basis for setting health‐based guidance values (e.g. an acceptable daily intake (ADI)). The Panel concluded that a concern for the genotoxicity of nicarbazin in Nilablend 200G cannot be excluded and that clarification on the mechanism of action of the test items would be needed. Therefore, the FEEDAP Panel is not in the position to establish an ADI for DNC on which to base the assessment of consumer safety. Nilablend 200G is considered toxic by inhalation, corrosive and irritant to eyes, slightly irritant to the skin but not a skin sensitiser. Inhalation exposure is considered a risk to persons handling the additive. The FEEDAP Panel cannot conclude on the safety of Nilablend 200G for the environment due to a possible risk for aquatic compartment (freshwater) for DNC. The efficacy of Nilablend? 200G was demonstrated.
 
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日期:2021-03-23
 
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